Irene Dunne (born Irene Marie Dunn; December 20, 1898 – September 4, 1990) was an American actress who appeared in films during the Golden Age of Hollywood. She is best known for her comedic roles, though she performed in films of other genres.

After her father died when she was 14, Dunne's family relocated from Kentucky to Indiana. She was determined to become an opera singer, but when she was rejected by The Met, she performed in musicals on Broadway until she was scouted by RKO and made her Hollywood film debut in the musical Leathernecking (1930). She later starred in the successful musical Show Boat (1936).

Dunne starred in 42 movies and was nominated five times for the Academy Award for Best Actress—for her performances in the western drama Cimarron (1931), the screwball comedies Theodora Goes Wild (1936) and The Awful Truth (1937), the romance Love Affair (1939), and the drama I Remember Mama (1948). Dunne is considered one of the finest actresses never to have won an Academy Award. She is also regarded as one of the best comedic actresses in the screwball genre. Her last film role was in 1952, and she also starred in numerous television anthology episodes and performed on radio. Dunne was nicknamed "The First Lady of Hollywood" for her regal manner despite being proud of her Irish-American, country-girl roots.

Dunne devoted her retirement to philanthropy. She was chosen by President Dwight D. Eisenhower as a delegate for the United States to the United Nations; in that capacity, she advocated for world peace and highlighted refugee-relief programs. Dunne received a Laetare Medal from the University of Notre Dame, and a papal knighthood—Dame of the Order of the Holy Sepulchre. In 1985, she was awarded a Kennedy Center Honor for her services to the arts.