Henry William George Lupino (16 June 1892 – 10 November 1959) professionally Lupino Lane, was an English actor and theatre manager, and a member of the famous theatrical Lupino family, which eventually included his cousin, the screenwriter/director/actress Ida Lupino. Lane started out as a child performer, known as "Little Nipper", and went on to appear in a wide range of theatrical, music hall, and film performances.

Lupino Lane is best known in the United Kingdom for playing Bill Snibson in the play and film Me and My Girl, which popularized the song-and-dance routine "The Lambeth Walk". In America he is remembered as an acrobatic star of silent comedy shorts produced between 1925 and 1929. Lane was especially well suited to physical comedy because he was double-jointed, and his limber frame was capable of performing dazzling acrobatics. One of his unique feats had him on the floor, sitting or reclining, and suddenly thrusting his legs forward and leaping to his feet (as seen in his 1927 short Hello Sailor).

Lane married actress Violet Blythe on 10 February 1917, and their son was the actor Lauri Lupino Lane (1921–1986). Lane's brothers were the actors Wallace Lupino and Stanley Lupino, and his nephew (Wallace's son) was another actor, Richard Lupino.